Ketamine alleviates bradykinin-induced disruption of the mouse cerebrovascular endothelial cell-constructed tight junction barrier via a calcium-mediated redistribution of occludin polymerization
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- 作者：Jui-Tai Chena ; b ; Yi-Ling Linc ; Ta-Liang Chend ; Yu-Ting Taib ; Cheng-Yu Chena ; Ruei-Ming Chen ; PhDc ; d ; e ; f ; rmchen@tmu.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ketamine ; Blood-brain barrier (BBB) ; Bradykinin ; Calcium influx ; Cerebrovascular endothelial cells ; Occludin tight junction
- 刊名：Toxicology
- 出版年：2016
- 出版时间：10 August 2016
- 年：2016
- 卷：368-369
- 期：Complete
- 页码：142-151
- 全文大小：3383 K
文摘
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Ketamine could suppress bradykinin-induced intracellular calcium mobilization.
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Ketamine induced B1R protein and mRNA expressions but did not change B2R protein levels.
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Ketamine attenuated bradykinin-induced redistribution of occludin tight junctions.
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Ketamine prevented bradykinin-induced breakage of the MCEC-constructed tight junction barrier.