Off-target effect of the cPLA2α inhibitor pyrrophenone: Inhibition of calcium release from the endoplasmic reticulum
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- 作者：Bogeon Yuna ; HeeJung Leea ; Heather Ewingb ; Michael H. Gelbb ; Christina C. Lesliea ; lesliec@njhealth.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：cPLA2α ; Calcium ; Pyrrophenone ; Endoplasmic reticulum ; Mitochondria
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：7 October 2016
- 年：2016
- 卷：479
- 期：1
- 页码：61-66
- 全文大小：908 K
文摘
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cPLA2α inhibitor pyrrophenone blocks calcium increase and C2 domain translocation.
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Pyrrophenone inhibits ATP stimulated transfer of calcium from ER to mitochondria.
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Effects of pyrrophenone are off-target occurring in cPLA2α-deficient cells.
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Pyrrophenone targets a novel serine hydrolase that regulates calcium mobilization.