Modelling of tetracycline resistance gene transfer by commensal Escherichia coli food isolates that survived in gastric fluid conditions

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• 作者：Daekeun Hwang^a ; ^b ; Seung Min Kim^c ; Hyun Jung Kim^a ; ^b ; ^{hjkim@kfri.re.kr}
• 关键词：Escherichia coli ; Tetracycline resistance ; Gene transfer ; Simulated gastric fluid ; Survival ; Probabilistic exposure assessment
• 刊名：International Journal of Antimicrobial Agents
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：49
• 期：1
• 页码：81-87
• 全文大小：637 K
• 卷排序：49

文摘

Probabilistic exposure model was used to estimate antimicrobial resistance gene transfer in the human gut. Acid resistance and kinetic behaviour of E. coli survival were analysed in gastric pH conditions. Simulation results suggest that 22–33% of commensal E. coli can survive under gastric pH conditions of Koreans. Estimated mean tet(A) transfer rate by commensal E. coli was 1.68 × 10–4–8.15 × 10–4 log CFU/mL/h.