How do reactive oxygen species and calcium trigger mitochondrial membrane permeabilisation?
详细信息 查看全文
- 作者：Nicolas Tajeddine ; nicolas.tajeddine@uclouvain.be" class="auth_mail" title="E-mail the corresponding author
- 关键词：ΔΨm ; mitochondrial transmembrane potential ; CAD ; caspase-activated DNase ; CaM ; calmodulin ; CaMKII ; Ca2 ; +/calmodulin-dependent protein kinase II ; CypD ; cyclophilin D ; DISC ; death-inducing signalling complex ; FADD ; Fas-associated protein with death domain ; GSK-3β ; glycogen synthase kinase-3β ; HKII ; hexokinase II ; HTRA2 ; high temperature requirement protein A2 ; IAP ; inhibitors of apoptosis proteins ; IP3R ; inositol triphosphate receptor ; I/R ; ischemia/reperfusion ; JNK ; c-Jun N-terminal protein
- 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：1860
- 期：6
- 页码：1079-1088
- 全文大小：841 K
文摘
- •
Mitochondrial membrane permeabilisation (MMP) is a crucial step leading to cell death.
- •
In most models, ROS and mitochondrial Ca2 + cooperate to induce MMP.
- •
ROS directly target several components involved in MMP.
- •
However, the mechanisms by which mitochondrial Ca2 + induces MMP remain obscure.
- •
Ca2 + might require mitochondrial ROS generation as a mandatory step to trigger MMP.