Viral-mediated Zif268 expression in the prefrontal cortex protects against gonadectomy-induced working memory, long-term memory, and social interaction deficits in male rats
文摘
Gonadectomy negatively impacts PFC Zif268 expression, long-term memory, social interaction, and mood-related behaviors. mPFC AAV-Zif268 expression prevents GNX-induced reductions in Zif268, memory, and social interaction. Zif268 may serve as a non-hormonal treatment for cognitive declines associated with testosterone loss.