- 作者：Jamshid Roozbeh ; MD&lowast ; ; Maryam Sharifian ; MD&dagger ; ; maryam_sharifian@yahoo.com ; Ahmad Ghanizadeh ; MD&Dagger ; ; Ali Sahraian ; MD&Dagger ; ; Mohammad Mahdi Sagheb ; MD&lowast ; ; Sanaz Shabani&dagger ; ; Alireza Hamidian Jahromi ; MD ; MRCS¶ ; ; Mansoor Kashfi§ ; ; Raha Afshariani ; MD§ ;
- 刊名：Journal of Renal Nutrition
- 出版年：2011
- 出版时间：March 2011
- 年：2011
- 卷：21
- 期：2
- 页码：184-187
- 全文大小：74 K
Introduction
Depression is a common psychological symptom in patients undergoing chronic hemodialysis. In the general population, low serum zinc level is associated with major depression. The current study surveys the possible relationship between the prevalence of depression and plasma level of zinc in patients on hemodialysis (HD).Patients and Methods
A total of 135 patients with end-stage renal disease (ESRD) on HD were enrolled in the study. The severity of depression was assessed using Beck Depression Inventory (BDI). Plasma zinc level was measured from fasting samples.
Results
Mean age of the patients was 52.45 (standard deviation: 15.33) years. In all, 76 % of the patients had some degree of depression according to BDI scoring system (BDI >14). The mean level of plasma zinc in the depressed patients was significantly lower than the rest of the patients (67.46 ¡À 29.7 vs. 85.26 + 40.05).
Discussion
Zinc deficiency may be a reversible cause which might contribute to the increased rate of depression in HD patients. This is the first study reporting the association of zinc deficiency with the presence of depression in HD patients; therefore, these findings need further investigations.