Deleting the citrinin biosynthesis-related gene, ctnE, to greatly reduce citrinin production in Monascus aurantiacus Li AS3.4384

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• 作者：Zhen-Qiang Ning^a ; ^b ; ^c ; Hua Cui^b ; ^c ; Yang Xu^b ; ^c ; Zhi-Bing Huang^b ; ^c ; Zhui Tu^b ; ^c ; Yan-Ping Li^b ; ^c ; ^{liyanping@ncu.edu.cn}
• 关键词：Monascus aurantiacus ; Citrinin biosynthesis-related genes ; ctnE Gene ; Gene knockout
• 刊名：International Journal of Food Microbiology
• 出版年：2017
• 出版时间：16 January 2017
• 年：2017
• 卷：241
• 期：Complete
• 页码：325-330
• 全文大小：621 K
• 卷排序：241

文摘

A ctnE disruptant had been obtained through homologous recombination method. The △ctnE has notably reduced the citrinin production by 96% in Monascus aurantiacus. The △ctnE has markedly increased the pigment production by 40% in M. aurantiacus. The role of ctnE gene in citrinin biosynthesis has been confirmed.