Survival Impact of Early Post-Transplant Toxicities in Pediatric and Adolescent Patients Undergoing Allogeneic Hematopoietic Cell Transplantation for Malignant and Nonmalignant Diseases: Recognizing Risks and Optimizing Outcomes
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- 作者：Naima Al Mulla1 ; Justine M. Kahn1 ; Zhezhen Jin1 ; 2 ; Mahvish Qureshi1 ; Esra Karamehmet1 ; Grace Yoon-Jeong Kim3 ; Anya L. Levinson1 ; Monica Bhatia1 ; James H. Garvin1 ; Diane George1 ; Andrew L. Kung1 ; Prakash Satwani1 ; Ps2087@cumc.columbia.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pediatric ; Adolescent ; Morbidity ; Mortality ; Predictors ; Allogeneic
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：22
- 期：8
- 页码：1525-1530
- 全文大小：474 K
文摘
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Pediatric allogeneic stem cell transplant patients have high rates of post-transplant toxicities.
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Reduced toxicity is not less toxic than myeloablative conditioning in this population.
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Patient age ≥ 12 years is a significant risk factor for early post-transplant toxicities.
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Performance score < 90 and ≥3 post-transplant toxicities are associated with increased mortality.