Cell-specific modulation of monocarboxylate transporter expression contributes to the metabolic reprograming taking place following cerebral ischemia
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- 作者：K. Rosafioa ; &dagger ; ; katia.rosafio@unil.ch" class="auth_mail" title="E-mail the corresponding author ; X. Castillob ; &dagger ; ; ximena.castillo@unil.ch" class="auth_mail" title="E-mail the corresponding author ; L. Hirtb ; lorenz.hirt@unil.ch" class="auth_mail" title="E-mail the corresponding author ; L. Pellerina ; luc.pellerin@unil.ch" class="auth_mail" title="E-mail the corresponding author
- 关键词：EDTA ; ethylenediaminetetraacetic acid ; MCAO ; middle cerebral artery occlusion ; MCTs ; monocarboxylate transporters ; PBS ; phosphate-buffered saline ; rCBF ; regional cerebral blood flow ; TBS ; Tris-Buffered-Saline
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：11 March 2016
- 年：2016
- 卷：317
- 期：Complete
- 页码：108-120
- 全文大小：6858 K
文摘
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Expression of cerebral monocarboxylate transporters was determined 1 and 24 h following transient ischemia in mice.
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After 1 h, MCT1, MCT2 and MCT4 expressions were upregulated in the ipsilateral and contralateral striatum and cortex.
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Neuronal MCT2 but also MCT1 expression, astrocytic MCT4 expression and microvessel MCT1 expression all increased at 1 h.
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After 24 h, overall MCT2 and MCT4 expressions decreased in the ipsilateral and contralateral striatum and cortex.
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Neuronal MCT2 expression was reduced but MCT4 expression appeared while microvessels exhibited MCT2 expression at 24 h.