Nutritionally relevant concentrations of resveratrol and hydroxytyrosol mitigate oxidative burst of human granulocytes and monocytes and the production of pro-inflammatory mediators in LPS-stimulated RAW 264.7 macrophages

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• 作者：Elisabetta Bigagli^a ; ^{elisabetta.bigagli@unifi.it} ; Lorenzo Cinci^a ; Sara Paccosi^b ; Astrid Parenti^b ; Mario D'Ambrosio^a ; Cristina Luceri^a
• 关键词：Inflammation ; Oxidative burst ; Resveratrol ; Hydroxytyrosol ; miR-146a ; Nrf2
• 刊名：International Immunopharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：43
• 期：Complete
• 页码：147-155
• 全文大小：787 K
• 卷排序：43

文摘

Low concentrations of resveratrol and hydroxytyrosol attenuate inflammation. Resveratrol and hydroxytyrosol mitigate oxidative stress. Resveratrol and hydroxytyrosol decrease PGE2 levels. miR-146a and Nrf2 are involved in the observed anti-inflammatory effects.