Cyclic guanosine monophosphate compartmentation in human vascular smooth muscle cells
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- 作者：Joana Feiteiro ; Ignacio Verde ; Elisa Cairrã ; o ; ecairrao@fcsaude.ubi.pt" class="auth_mail" title="E-mail the corresponding author
- 关键词：ANP ; atrial natriuretic peptide ; BKCa ; large-conductance Ca2 ; + activated potassium channels ; cAMP ; cyclic adenosine 3 ; 5&prime ; -monophosphate ; CNG ; cyclic nucleotide-gated ; cGMP ; cyclic guanosine 3 ; 5&prime ; -monophosphate ; HUASMC ; human umbilical artery smooth muscle cell ; ICNG ; cyclic nucleotide-gated current ; IK ; potassium current ; IBMX ; 3-Isobutyl-1-methylxanthine ; KV ; voltage-gated potassium channels ; NO ; nitric oxide ; PDE ; phosphodiesterase ; pGC ; particulate guanylyl cyclase ; PKG ; protei
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：28
- 期：3
- 页码：109-116
- 全文大小：1027 K
文摘
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The cGMP is compartmentalized in human vascular smooth muscle cells.
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The compartmentalization of cGMP is controlled by specific PDE.
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The cGMP pool formed near plasma membrane is controlled by PDE5 and PDE3.
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The cGMP pool localized in the cytosol is only controlled by PDE3.