Involvement of nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of tropisetron and ondansetron in mice forced swimming test and tail suspension test
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- 作者：Arya Haj-Mirzaiana ; b ; 1 ; Nastaran Kordjazya ; b ; 1 ; Shayan Amiria ; b ; Arvin Haj-Mirzaiana ; b ; Hossien Amini-khoeia ; b ; Sattar Ostadhadia ; b ; c ; AhmadReza Dehpoura ; b ; dehpoura@sina.tums.ac.ir" class="auth_mail" title="E-mail the corresponding author ; dehpour@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：5-HT ; 5-hydroxytryptamine ; NO ; nitric oxide ; NOS ; nitric oxide synthase ; iNOS ; inducible nitric oxide synthase ; nNOS ; neuronal nitric oxide synthase ; cGMP ; cyclic guanosine monophosphate ; FST ; forced swimming test ; TST ; tail suspension test ; OFT ; open-field test ; i.p. ; intraperitoneal ; NIH ; National Institutes of Health ; l-NAME ; NG-l-arginine methyl ester ; 7-NI ; 7-nitroindazole ; l-arg ; l-arginine ; PDE ; phosphodiesterase ; ANOVA ; analysis of variance ; PFC ; prefrontal cortex
- 刊名：European Journal of Pharmacology
- 出版年：2016
- 出版时间：5 June 2016
- 年：2016
- 卷：780
- 期：Complete
- 页码：71-81
- 全文大小：1874 K
文摘
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5-HT3 antagonists showed an antidepressant effect in the mouse FST and TST.
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nNOS inhibitor enhanced the effect of 5-HT3 antagonists in behavioral tests.
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NO precursor and 5-PDE inhibitor attenuated the effect of 5-HT3 antagonists.
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5-HT3 antagonists and nNOS inhibitor decreased the hippocampal nitrite levels.
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Antidepressant effect of 5-HT3 antagonists is partly mediated via NO-cGMP pathway.