Analyses of the role of the glucocorticoid receptor gene polymorphism (rs41423247) as a potential moderator in the association between childhood overweight, psychopathology, and clinical outcomes in Eating Disorders patients: A 6 years follow up study

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• 作者：Giovanni Castellini^a ; ^b ; Lorenzo Lelli^a ; Andrea Tedde^a ; Irene Piaceri^a ; Silvia Bagnoli^a ; Ersilia Lucenteforte^a ; Sandro Sorbi^a ; Alessio Maria Monteleone^c ; James J. Hudziak^d ; ^e ; ^f ; Benedetta Nacmias^a ; Valdo Ricca^a ; ^{valdo.ricca@unifi.it" class="auth_mail" title="E-mail the corresponding author}
• 关键词：BclI receptor gene polymorphism ; rs41423247 ; Eating Disorders ; Childhood overweight
• 刊名：Psychiatry Research
• 出版年：2016
• 出版时间：30 September 2016
• 年：2016
• 卷：243
• 期：Complete
• 页码：156-160
• 全文大小：229 K

文摘

Childhood overweight and the SNP rs41423247 of the glucocorticoid receptor gene (GR) were reported to represent predisposing factors for Eating Disorders (EDs). The distribution of the polymorphism was evaluated in 202 EDs patients, and in 116 healthy subjects. The Structured Clinical Interview for the DSM-IV and self-reported questionnaires were administered at the admission to the clinic and at 3 time points (end of a cognitive behavioral therapy, 3 and 6 years follow up). G-allele was associated with childhood overweight, depressive disorder comorbidity, and diagnostic instability. G-allele carriers reporting childhood overweight showed greater frequency of subjective binge eating and emotional eating.