Integration of HIV-1 caused STAT3-associated B cell lymphoma in an AIDS patient
详细信息 查看全文
- 作者：Harutaka Katano ; Yuko Sato ; Satomi Hoshino ; Natsuo Tachikawa ; Shinichi Oka ; Yasuyuki Morishita ; Takaomi Ishida ; Toshiki Watanabe ; William N. Rom ; Shigeo Mori ; Tetsutaro Sata ; Michael D. Weiden ; Yoshi
- 关键词：HIV-1 ; Integration ; AIDS-related lymphoma ; STAT3
- 刊名：Microbes and Infection
- 出版年：2007
- 出版时间：November-December 2007
- 年：2007
- 卷：9
- 期：14-15
- 页码：1581-1589
- 全文大小：1000 K
文摘
Signal transducer and activator of transcription 3 (STAT3) is a DNA-binding transcription factor activated by multiple cytokines and interferons. High expression of STAT3 has also been implicated in cancer and lymphoma. Here, we show a case of B cell lymphoma in which a defective human immunodeficiency virus 1 (HIV-1) integrated upstream of the first STAT3 coding exon. The lymphoma cells with anaplastic large cell morphology formed multiple nodular lesions in the lung of an acquired immunodeficiency syndrome (AIDS) patient with Kaposi's sarcoma. The provirus had a 5′ long terminal repeat (LTR) deletion, but the 3′ LTR had stronger promoter activity than the STAT3 promoter in reporter assays. Immunohistochemistry showed increased expression of STAT3 in the nuclei of lymphoma cells. Transfection of STAT3 resulted in transient cell proliferation in primary B cells in vitro. Although this is a very rare case of HIV-1-integrated lymphoma, these data suggest that up-regulation of STAT3 caused by HIV-1 integration resulted in the development of B cell lymphoma in this special case.