Colloid, adhesive and release properties of nanoparticular ternary complexes between cationic and anionic polysaccharides and basic proteins like bone morphogenetic protein BMP-2

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• 作者：R. Petzold^b ; D. Vehlow^a ; ^b ; B. Urban^a ; A.L. Grab^c ; E.A. Cavalcanti-Adam^c ; ^d ; V. Alt^e ; M. Mü ; ller^a ; ^b ; ^{mamuller@ipfdd.de}
• 关键词：Bone healing ; Bone substituting materials ; Drug delivery system ; Protein delivery ; Biopolymer coating ; Polyelectrolyte complex nanoparticles ; Polysaccharides ; Bone morphogenetic protein ; FTIR spectroscopy ; Circular dichroism
• 刊名：Colloids and Surfaces B: Biointerfaces
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：151
• 期：Complete
• 页码：58-67
• 全文大小：1313 K
• 卷排序：151

文摘

An adhesive delivery system for bone morphogenetic protein 2 (BMP-2) is described. The BMP-2 delivery system bases on polyelectrolyte complex nanoparticles (PEC NP). Papain and chymotrypsin charged and sized similar to BMP-2 served as model proteins. BMP-2 showed slowest release kinetics within 14 days and lowest initial burst. BMP-2 released from PEC NP coatings revealed significant activity in myoblast cells.