The H-bond network surrounding the pyranopterins modulates redox cooperativity in the molybdenum-bisPGD cofactor in arsenite oxidase
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- 作者：Simon Duvala ; Joanne M. Santinib ; David Lemairec ; Florence Chaspould ; Michael J. Russelle ; Stephane Grimaldia ; Wolfgang Nitschkea ; Barbara Schoepp-Cotheneta ; schoepp@imm.cnrs.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Aio ; arsenite oxidase ; AMPSO ; 3-([1 ; 1-Dimethyl-2-hydroxyethyl]amino)-2-hydroxypropanesulfonic acid ; EPR ; Electron Paramagnetic Resonance ; HEPES ; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid ; Ks ; stability constant ; MES ; 2-(N-morpholino)ethanesulfonic acid ; Mo ; Molybdenum ; MOPS ; 3-(N-morpholino)propanesulfonic acid ; PGD ; Pyranopterin Guanosine Dinucleotide
- 刊名：Biochimica et Biophysica Acta (BBA) - Bioenergetics
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：1857
- 期：9
- 页码：1353-1362
- 全文大小：1270 K
文摘
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The Mo-bisPGD enzyme arsenite oxidase displays strong redox cooperativity
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Optical titrations appear as a powerful method for assessing Mo-redox properties
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The H-bond network surrounding the pyranopterins-ligands modulates cooperativity
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20">The Mo-bisPGD cofactor resembles quinones with respect to redox properties