Pappa2 deletion alters IGFBPs but has little effect on glucose disposal or adiposity
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- 作者：Julian K. Christians ; jkchrist@sfu.ca" class="auth_mail" title="E-mail the corresponding author ; Amrit K. Bath ; Neilab Amiri
- 关键词：ALS ; acid-labile subunit ; AUC ; area under the curve ; GTT ; glucose tolerance test ; HFD ; high-fat diet ; IGF ; insulin-like growth factor ; IGFBP ; insulin-like growth factor binding protein ; PAPP-A2 ; pregnancy associated plasma protein-A2 ; piAUC ; positive incremental area under the curve
- 刊名：Growth Hormone & IGF Research
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：25
- 期：5
- 页码：232-239
- 全文大小：611 K
文摘
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Pregnancy-associated plasma protein-A2 (PAPP-A2) is a protease of IGFBP-5.
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Deletion of Pappa2 increased circulating IGFBP-5 and IGF-I and decreased IGFBP-3.
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Deletion of Pappa2 did not affect fasting glucose levels or glucose tolerance.
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Deletion of Pappa2 had no effect on adiposity on a high-fat diet.