Induction of cytochromes P450 1A1 and 1A2 suppresses formation of DNA adducts by carcinogenic aristolochic acid I in rats in vivo
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- 作者：Helena Dračí ; nská ; a ; Franti&scaron ; ek Bá ; rtaa ; Kateřina Levová ; a ; Alena Hudecová ; a ; Michaela Moserová ; a ; Heinz H. Schmeiserb ; Klaus Kopkab ; c ; Eva Freia ; Volker M. Arltd ; Marie Stiborová ; a ; stiborov@natur.cuni.cz" class="auth_mail" title="E-mail the corresponding author
- 关键词：AA ; aristolochic acid ; AAI ; aristolochic acid I ; AAII ; aristolochic acid II ; AAIa ; aristolochic acid Ia ; AAN ; aristolochic acid nephropathy ; BEN ; Balkan endemic nephropathy ; bw ; body weight ; cT ; cycle threshold ; CYP ; cytochrome P450 ; dA-AAI ; 7-deoxyadenosine-N6-yl)aristolactam I ; dA-AAII ; 7-deoxyadenosine-N6-yl)aristolactam II ; dG-AAI ; 7-deoxyguanosin-N2-yl)aristolactam I ; HPLC ; high performance liquid chromatography ; HUFs ; Hupki (human TP53 knock-in) mouse fibroblasts ; MROD ; methoxyresorufin O-
- 刊名：Toxicology
- 出版年：2016
- 出版时间：17 February 2016
- 年：2016
- 卷：344-346
- 期：Complete
- 页码：7-18
- 全文大小：1918 K
文摘
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Oxidation and reduction of aristolochic acid I (AAI) dictate its (geno)toxicity in vivo.
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Cytochrome P450 (CYP) 1A1 and 1A2 are induced in rats treated with Sudan I and AAI.
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Induced CYP1A enzyme activity resulted in decreased AAI-DNA adduct levels in vivo.
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CYP1A1 and 1A2 mainly detoxify AAI and attenuate its genotoxicity in vivo.