The role of S100a4 (Mts1) in Apc- and Smad4-driven tumour onset and progression
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- 作者：Yaser Atlasia ; 1 ; Yaser.Atlasi@ncmls.ru.nl" class="auth_mail" title="E-mail the corresponding author ; Rubina Nooria ; Ivana Marolina ; Patrick Frankena ; Joana Brandaoa ; Katharina Biermanna ; Paola Collinib ; Mariam Grigorianc ; d ; Eugene Lukanidinc ; d ; Noona Ambartsumianc ; d ; Riccardo Foddea ; r.fodde@erasmusmc.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：S100a4 ; Colorectal cancer ; Desmoids ; Mts1 ; Apc ; Smad4
- 刊名：European Journal of Cancer
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：68
- 期：Complete
- 页码：114-124
- 全文大小：3800 K
文摘
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Genetic ablation or overexpression of S100a4 in both Apc- and Smad4-mutant mice do not affect intestinal tumour initiation.
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S100a4 overexpression in Apc1638N/+/KRASV12G mice increases the dissemination of intestinal tumour cells to the liver.
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S100a4 deficiency results in a reduction of desmoids suggesting a novel role for S100a4 in desmoid formation.
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S100a4 is co-expressed together with mesenchymal stem cell (MSC) markers in desmoid tumours.