The impact of the C-terminal domain on the gating properties of MscCG from Corynebacterium glutamicum
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- 作者：Yoshitaka Nakayamaa ; Michael Beckerb ; Haleh Ebrahimiana ; c ; Tomoyuki Konishid ; Hisashi Kawasakid ; Reinhard Krä ; merb ; Boris Martinaca ; b.martinac@victorchang.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：NCgl1221 ; Mechanosensitive channel ; Glutamate efflux ; Gating hysteresis ; E. coli ; Spheroplasts ; Liposomes ; Patch clamp
- 刊名：Biochimica et Biophysica Acta (BBA)-Biomembranes
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：1858
- 期：1
- 页码：130-138
- 全文大小：942 K
文摘
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The C-terminal domain of MscCG is an important component for the membrane tension sensing.
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The fourth transmembrane helix of MscCG regulates the gating threshold.
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The chimeric channel MscS-(C-MscCG) exhibits slower closing kinetics than MscS.
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MscS exhibits voltage-dependent closing at depolarizing membrane potentials.
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MscS and MscS-(C-MscCG) tend to remain open at the resting membrane potential.