Diabetes and mucormycosis: A complex interplay

详细信息    查看全文

• 作者：B. Rammaert ; F. Lanternier ; S. Poir¨¦e ; R. Kania ; O. Lortholary
• 关键词：Mucormycosis (zygomycosis) ; Diabetes ; Sinusitis ; Amphotericin B lipid derivatives ; Review
• 刊名：Diabetes Metabolism
• 出版年：2012
• 出版时间：June, 2012
• 年：2012
• 卷：38
• 期：3
• 页码：193-204
• 全文大小：1067 K

文摘

Mucormycosis is a life-threatening invasive fungal infection that arises particularly in diabetic patients with or without other underlying conditions such as haematological malignancies or the need for solid-organ transplantation. Rhino-orbito-cerebral involvement is the primary site of mucormycosis, but the paucity of signs may be a cause of delayed diagnosis. Thus, any case of documented non-bacteriological sinusitis in diabetic patients, even without ketoacidosis, should prompt suspicion of a mucormycosis diagnosis. To optimalize information for clinicians in charge of diabetic patients, this extensive review of the literature was carried out to provide an overview of mucormycosis specificities, epidemiology and pathophysiology in the setting of diabetes.