Methods of synthesis of hydrogels … A review
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- 作者：Muhammad Faheem Akhtar ; m_faheem1986@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Muhammad Hanif ; Nazar Muhammad Ranjha
- 关键词：Hydrogel ; Physical cross-linking ; Chemical cross-linking ; Degradation ; Drug release
- 刊名：Journal of the Saudi Pharmaceutical Society
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：24
- 期：5
- 页码：554-559
- 全文大小：410 K
文摘
Hydrogels are being investigated recently for the bioactive molecules (in particular pharmaceutical proteins) controlled release, such as matrices, and for the living cells encapsulation. Biodegradable nature of hydrogels has created much interest for drug delivery systems. The original three-dimensional structure disintegrates into nontoxic substances to ascertain an excellent biocompatibility of the gel. Chemical cross-linking is the highly resourceful method for the formation of hydrogels having an excellent mechanical strength. Cross-linkers used in hydrogel preparation should be extracted from the hydrogels before use due to their reported toxicity. Physically cross-linked methods for preparation of hydrogel are the alternate solution of cross-linker toxicity.