Analysis of ageing-associated grey matter volume in patients with multiple sclerosis shows excess atrophy in subcortical regions

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• 作者：Courtney A Bishop^a ; Rexford D Newbould^a ; Jean SZ Lee^b ; ^c ; Lesley Honeyfield^c ; Rebecca Quest^c ; Alessandro Colasanti^d ; Rehiana Ali^b ; Miriam Mattoscio^b ; Antonio Cortese^b ; ^e ; Richard Nicholas^b ; Paul M. Matthews^b ; Paolo A Muraro^b ; ¹ ; Adam D Waldman^b ; ^f ; ¹ ; ^{adam.waldman@ed.ac.uk}
• 关键词：Multiple sclerosis ; Magnetic resonance imaging ; Image analysis ; Grey matter ; Atrophy
• 刊名：NeuroImage: Clinical
• 出版年：2017
• 出版时间：2017
• 年：2017
• 卷：13
• 期：Complete
• 页码：9-15
• 全文大小：1024 K
• 卷排序：13

文摘

Compared brain atrophy within MS cohort differing only by age, and matched controls In early MS, subcortical GM atrophy is more than three times that of cortical GM. By contrast, WM and cortical GM do not show excess atrophy compared with controls. Hippocampal atrophy noted for clinically-matched younger versus older onset MS Proposed workflow for atrophy analysis of imaging data in MS