Stromal-Initiated Changes in the Bone Promote Metastatic Niche Development
详细信息 查看全文
- 作者：Xianmin Luo1 ; 2 ; 8 ; Yujie Fu1 ; 2 ; 8 ; Andrew J. Loza2 ; 3 ; Bhavna Murali1 ; 2 ; Kathleen M. Leahy1 ; 2 ; Megan K. Ruhland1 ; 2 ; Margery Gang1 ; 2 ; Xinming Su3 ; Ali Zamani4 ; Yu Shi4 ; Kory J. Lavine3 ; 5 ; David M. Ornitz5 ; 6 ; Katherine N. Weilbaecher3 ; 6 ; Fanxin Long3 ; 4 ; 5 ; 6 ; Deborah V. Novack3 ; 6 ; 7 ; Roberta Faccio4 ; 6 ; Gregory D. Longmore1 ; 2 ; 3 ; 6 ; Sheila A. Stewart1 ; 2 ; 3 ; 6 ; sheila.stewart@wustl.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：5 January 2016
- 年：2016
- 卷：14
- 期：1
- 页码：82-92
- 全文大小：3537 K
文摘
- •
Stromal changes in the bone drive tumor cell seeding and growth
- •
IL-6-expressing stromal cells are present in human bone
- •
Senescent osteoblasts drive increased osteoclastogenesis and tumor cell seeding
- •
Senescent-derived IL-6 drives localized osteoclastogenesis and tumor cell growth