Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice
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- 作者：Monica D. Bjø ; rge1 ; 7 ; Gunn A. Hildrestrand1 ; 7 ; Katja Scheffler1 ; 4 ; 7 ; Rajikala Suganthan1 ; Veslemø ; y Rolseth1 ; Anna Kuśnierczyk3 ; Alexander D. Rowe1 ; Cathrine B. Vå ; gbø ; 3 ; Susanne Vetlesen1 ; Lars Eide2 ; Geir Slupphaug3 ; 4 ; Yusaku Nakabeppu6 ; Timothy W. Bredy5 ; Arne Klungland1 ; Magnar Bjø ; rå ; s1 ; 4 ; magnar.bjoras@rr-research.no" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：29 December 2015
- 年：2015
- 卷：13
- 期：12
- 页码：2671-2678
- 全文大小：1932 K
文摘
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Ogg1−/−Mutyh−/− mice show increased activity, decreased anxiety, and impaired learning
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No apparent accumulation of 8-oxoG was found in mutant mouse brains compared to WT brains
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Differentially expressed genes in Ogg1−/−Mutyh−/− brains are important for anxiety