The effect of Platycodin D on the expression of cytoadherence proteins P1 and P30 in Mycoplasma pneumoniae models

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• 作者：Yan-li Meng^a ; Wei-ming Wang^a ; ^{wangweiming475@yahoo.com} ; Dan-dan Lv^a ; ¹ ; Qiu-xia An^a ; ¹ ; Wei-hong Lu^b ; ² ; Xin Wang^a ; Guixin Tang^b ; ²
• 关键词：M. pneumoniae ; Platycodin D ; P1 ; P30 ; Animal models
• 刊名：Environmental Toxicology and Pharmacology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：49
• 期：Complete
• 页码：188-193
• 全文大小：1243 K
• 卷排序：49

文摘

Platycodin D is one of the most important monomers of the Qinbaiqingfei pellet (Qinbai), which has already been approved as the first effective new Traditional Chinese Medicine used to fight against Mycoplasma pneumoniae (M. pneumoniae) in clinic in China. Platycodin D strongly inhibited P1 and P30 expression in M. pneumonia and high dosage of Platycodin D exhibited a greater effect on reducing P1 and P30 expression than low dose Platycodin D. Platycodin D prevented M. pneumoniae infection through inhibiting the expression of adhesion proteins, which might be one of the mechanisms for the anti-M. pneumoniae properties of Qinbai.