Non-coding RNAs as modulators of the cardiac fibroblast phenotype
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- 作者：Maria-Teresa Piccoli1 ; Christian Bä ; r1 ; Thomas Thum ; thum.thomas@mh-hannover.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：CFs ; cardiac fibroblasts ; ECM ; extracellular matrix ; Alpha-SMA ; alpha smooth muscle actin ; SMemb ; non-muscle myosin heavy chain ; TGF-beta ; transforming growth factor-beta ; IL1-beta ; interleukin 1-beta ; TNF-alpha ; tumor necrosis factor-alpha ; MI ; myocardial infarction ; MMPs ; matrix metalloproteinases ; Ang II ; angiotensin II ; EMT ; epithelial-mesenchymal transition ; EndMT ; endothelial-mesenchymal transition ; FSP1 ; fibroblast specific protein 1 ; DDR2 ; discoidin domain receptor 2 ; ncRNAs ; non-coding
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：92
- 期：Complete
- 页码：75-81
- 全文大小：460 K
文摘
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Dysfunction of cardiac fibroblasts is a hallmark of most cardiac pathologies and deeply affects heart function.
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Non-coding RNAs are involved in the regulation of fibroblast functions.
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Non-coding RNAs can be manipulated in vivo to modulate fibroblast phenotype.