Chemosensory signaling controls motility and subcellular polarity in Myxococcus xanthus

详细信息    查看全文

• 作者：Christine Kaimer ; James E Berleman ; David R Zusman ^{zusman@berkeley.edu}
• 刊名：Current Opinion in Microbiology
• 出版年：2012
• 出版时间：December, 2012
• 年：2012
• 卷：15
• 期：6
• 页码：751-757
• 全文大小：952 K

文摘

Myxococcus xanthus is a model system for the study of dynamic protein localization and cell polarity in bacteria. M. xanthus cells are motile on solid surfaces enabled by two forms of motility. Motility is controlled by the Che-like Frz pathway, which is essential for fruiting body formation and differentiation. The Frz signal is mediated by a GTPase/GAP protein pair that establishes cell polarity and directs the motility systems. Pilus driven motility at the leading pole of the cell requires dynamic localization of two ATPases and the coordinated production of EPS synthesis. Gliding motility requires dynamic movement of large protein complexes, but the mechanism by which this system generates propulsive force is still an active area of investigation.