Influence of Absorption, Distribution, Metabolism, and Excretion Genomic Variants on Tacrolimus/Sirolimus Blood Levels and Graft-versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation
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- 作者：Samer K. Khaled1 ; 2 ; samerkm@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Joycelynne M. Palmer3 ; Josef Herzog4 ; Tracey Stiller3 ; Ni-Chun Tsai3 ; David Senitzer5 ; Xueli Liu3 ; Sandra H. Thomas1 ; Sepideh Shayani6 ; Jeffrey Weitzel4 ; Stephen J. Forman1 ; Ryotaro Nakamura1
- 关键词：Immunosuppressant ; Drug absorption ; distribution ; metabolism ; and excretion (ADME) ; Pharmacogenetics
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：22
- 期：2
- 页码：268-276
- 全文大小：615 K
文摘
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Absorption, distribution, metabolism, and excretion (ADME) genetic variants were studied in hematopoietic cell transplant recipients on immunosuppression using a panel covering >99% of the PharmaADME working group list.
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Absorption, distribution, metabolism, and excretion variants may influence drug levels and concentration/dose ratios of tacrolimus/sirolimus, as well as incidence of clinical acute graft-versus-host disease.