Copper(I)-catalyzed domino allylic C(sp³)-H aminative cyclization/oxidative reaction and its application toward pyrrolo[3,4-d]pyrimidinones

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• 作者：Zhiguo Zhang ; ^{zhangzg@htu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Xiangqian Yan ; Guisheng Zhang ; Qingfeng Liu ; Nana Ma ; Tongxin Liu ; Lei Shi ^{zgs6668@yahoo.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Pyrimidine derivatization ; Copper-catalyzed ; C(sp3)&ndash ; H functionalization ; C&ndash ; N formation ; Pyrrolo[3 ; 4-d]pyrimidinones
• 刊名：Tetrahedron
• 出版年：2016
• 出版时间：2 June 2016
• 年：2016
• 卷：72
• 期：22
• 页码：3077-3083
• 全文大小：806 K

文摘

An efficient tandem copper(I)-catalyzed intramolecular allylic C(sp³)–H functionalization/C–N formation/oxidative reaction of 6-methyl-dihydropyrimidine-2-one-5-carboxamides has been developed for the synthesis of substituted 2H-pyrrolo[3,4-d]pyrimidine-2,5,7(3H,6H)-trione derivatives in a single step in good to excellent yields.