Copper(I)-catalysed amidation and successive oxidation of benzylic C(sp³)-H bond: synthesis of 1H-pyrrolo[3,4-b]quinoline-1,3(2H)-diones

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• 作者：Xiangqian Yan ; Zhiguo Zhang ; ^{zhangzg@htu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Guisheng Zhang ; ^{zgs6668@yahoo.cn" class="auth_mail" title="E-mail the corresponding author} ; Nana Ma ; Qingfeng Liu ; Tongxin Liu ; Lei Shi
• 关键词：Copper-catalysed ; Amidation ; C&ndash ; H functionalization ; C&ndash ; N formation ; Pyrrolo[3 ; 4-b]quinolindione
• 刊名：Tetrahedron
• 出版年：2016
• 出版时间：21 July 2016
• 年：2016
• 卷：72
• 期：29
• 页码：4245-4251
• 全文大小：616 K

文摘

An efficient copper(I)-catalysed intramolecular arylmethyl C(sp³)–H direct oxidative amidation reaction has been developed for the preparation of drug-like 1H-pyrrolo[3,4-b]quinoline-1,3(2H)-diones from readily available 2-methyl-3-carbamoyl-quinolines.