Folic acid and trastuzumab conjugated redox responsive random multiblock copolymeric nanocarriers for breast cancer therapy: In-vitro and in-vivo studies

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• 作者：Arun Kumar^a ; ^b ; Shantanu V. Lale^a ; ^b ; M.R. Aji Alex^a ; ^b ; Veena Choudhary^c ; Veena Koul^a ; ^b ; ^{veenak_iitd@yahoo.com} ; ^{veenak@cbme.iitd.ac.in}
• 关键词：Ehrlich&rsquo ; s ascites tumor ; Multiblock copolymer ; Redox sensitive nanoparticles ; Trastuzumab
• 刊名：Colloids and Surfaces B: Biointerfaces
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：149
• 期：Complete
• 页码：369-378
• 全文大小：2641 K
• 卷排序：149

文摘

Redox responsive polymeric nanoparticles were developed for cancer therapeutics. High drug loading content of ∼22% was achieved with the polymeric nanoparticles. In-vitro studies in cancer cell lines showed significantly enhanced cellular uptake. In-vivo studies revealed 91% tumor regression in Ehrlich ascites tumor.