Folic acid-modified soy protein nanoparticles for enhanced targeting and inhibitory

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• 作者：Xu Cheng ; Xin Wang ; Zhipeng Cao ; Weijing Yao ; Jun Wang ; Rupei Tang ; ^{tangrp99@iccas.ac.cn}
• 关键词：Soy protein ; Nanoparticles ; Drug delivery ; Folic acid ; Antitumor
• 刊名：Materials Science and Engineering: C
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：71
• 期：Complete
• 页码：298-307
• 全文大小：2141 K
• 卷排序：71

文摘

Soy protein isolate was hydrolyzed by compound enzymes to prepare nanoparticles. Nanoparticles are spherical like and very stable in various conditions. Cellular uptake and cytotoxicity were investigated in monolayer cell model. 3-D multicellular spheroids were using to evaluate nanoparticles' effect. Antitumor effect of these nanoparticles was measured using H22 tumor-bearing mice.