Endothelial dysfunction in rats with ligature-induced periodontitis: Participation of nitric oxide and cycloxygenase-2-derived products
详细信息 查看全文
- 作者：Paula Campia ; Bruno Schneider Herreraa ; b ; 1 ; Flavia Neto de Jesusa ; Mauro Napolitanoa ; Simone Aparecida Teixeiraa ; Aline Maia-Dantasa ; Luis Carlos Spolidoriob ; Eliana Hiromi Akaminea ; Marcia Pinto Alves Mayerc ; Maria Helena Catelli de Carvalhoa ; Soraia Katia Pereira Costaa ; Marcelo Nicolas Muscaraa ; muscara@usp.br" class="auth_mail" title="E-mail the corresponding author ; mnmuscara@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Periodontitis ; Endothelium ; Vascular ; Aorta ; Nitric oxide ; Cyclooxygenase 2 ; Inflammation
- 刊名：Archives of Oral Biology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：63
- 期：Complete
- 页码：66-74
- 全文大小：1405 K
文摘
- •
Unilateral ligature-induced periodontitis affects rat aorta vasomotriciy.
- •
Endothelial-dependent vasorelaxation and adrenergic vasoconstriction are impaired.
- •
Endothelium removal, iNOS and COX-2 blockade restore the impaired vasomotricity.
- •
No periodontal bacteria were detected in the aorta.
- •
Aorta from rats with periodontitis show decreased eNOS and increased iNOS and COX-2.