Stem cell plasticity and tumour formation
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- 作者：Malcolm R. Alison ; Matthew J. Lovell ; Natalie C. Direkze ; Nicholas A. Wright and Richard Poulsom
- 关键词：Haematopoietic stem cells ; Transdifferentiation ; Cell fusion ; Neovascularisation ; Endothelial progenitor cells ; Mesenchymal stem cells ; Myofibroblasts ; Desmoplasia ; Tumour stroma
- 刊名：European Journal of Cancer
- 出版年：2006
- 出版时间：June 2006
- 年：2006
- 卷：42
- 期：9
- 页码：1247-1256
- 全文大小：579 K
文摘
Stem cell plasticity refers to the ability of certain stem cells to switch lineage determination and generate unexpected cell types. This review applies largely to bone marrow cells (BMCs), which appear to contribute positively to the regeneration of several damaged non-haematopoietic tissues. This beneficial effect on regeneration may be a direct result of BMCs giving rise to organ parenchymal cells. Alternatively, it could be due to BMCs fusing with existing parenchymal cells, or providing paracrine growth factor support, or contributing to neovascularisation. In the context of oncology, BMC derivation of the tumour stroma and vasculature has profound biological and therapeutic implications, and there are several examples of carcinomas seemingly being derived from BMCs.