Genetically re-engineered K562 cells significantly expand and functionally activate cord blood natural killer cells: Potential for adoptive cellular immunotherapy

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• 作者：Janet Ayello^a ; Jessica Hochberg^a ; Allyson Flower^a ; Yaya Chu^a ; Laxmi V. Baxi^b ; William Quish^a ; Carmella van de Ven^a ; Mitchell S. Cairo^a ; ^c ; ^d ; ^e ; ^f ; ^{mitchell_cairo@nymc.edu}
• 刊名：Experimental Hematology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：46
• 期：Complete
• 页码：38-47
• 全文大小：1315 K
• 卷排序：46

文摘

Cord blood (CB) mononuclear cells were expanded with artificial antigen-presenting cells. Natural killer (NK)-cell expansion, phenotype, and cytotoxicity against B-cell non-Hodgkin lymphoma were evaluated. Expanded NK-cell cytotoxicity was increased compared with controls in vitro. Expanded NK cells were associated with decreased tumor burden and increased survival in vivo. The potential future use of expanded NK cells as adoptive cellular immunotherapy after umbilical CB transplantation was explored.