Inactivation of Geminin in neural crest cells affects the generation and maintenance of enteric progenitor cells, leading to enteric aganglionosis
详细信息 查看全文
- 作者：Athanasia Stathopouloua ; Dipa Natarajanb ; 1 ; Pinelopi Nikolopouloua ; Alexandra L. Patmanidia ; Zoi Lygerouc ; Vassilis Pachnisb ; Stavros Taravirasa ; taraviras@med.upatras.gr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Geminin ; Neural crest cells ; Self-renewal ; Differentiation ; Enteric nervous system
- 刊名：Developmental Biology
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：409
- 期：2
- 页码：392-405
- 全文大小：15898 K
文摘
- •
Geminin is expressed in migrating neural crest cells (NCCs) and their derivatives.
- •
Geminin is essential for the generation of the enteric nervous system.
- •
Enteric NCCs lacking Geminin show defects in self-renewal and increased apoptosis.
- •
Deletion of Geminin from NCCs in mice leads to intestinal aganglionosis.