Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion
详细信息 查看全文
- 作者：Ivan Qué ; tier1 ; Jacqueline J.T. Marshall2 ; Bradley Spencer-Dene3 ; Sylvie Lachmann2 ; Adele Casamassima2 ; Claudio Franco4 ; Sarah Escuin5 ; Joseph T. Worrall6 ; Priththivika Baskaran1 ; Vinothini Rajeeve6 ; Michael Howell3 ; Andrew J. Copp5 ; Gordon Stamp3 ; Ian Rosewell7 ; Pedro Cutillas6 ; Holger Gerhardt8 ; Peter J. Parker2 ; 9 ; peter.parker@crick.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Angus J.M. Cameron1 ; a.cameron@qmul.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：PKC ; protein kinase C ; PKN ; Protein kinase N ; MEF ; mouse embryonic fibroblasts ; ES cells ; Embryonic stem cells ; 4-OHT ; 4-hydroxytamoxifen ; NCCs ; neural crest cells
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：26 January 2016
- 年：2016
- 卷：14
- 期：3
- 页码：440-448
- 全文大小：3298 K
文摘
- •
PKN2, but not PKN1 or PKN3, is essential during mouse embryogenesis
- •
PKN2 knockout causes severe cardiovascular and morphogenetic abnormalities
- •
PKN2 is required for mesenchymal growth and neural crest migration in vivo