Sonic hedgehog is a chemotactic neural crest cell guide that is perturbed by ethanol exposure
详细信息 查看全文
- 作者：Ezequiel J. Tolosaa ; b ; Martí ; n E. Ferná ; ndez-Zapicob ; Natalia L. Battiatoa ; Roberto A. Rovasioa ; rrovasio@yahoo.com.ar" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cell guiding ; Cell migration ; Chemotaxis ; Chick embryo ; Ethanol ; Neural crest cells ; Sonic hedgehog
- 刊名：European Journal of Cell Biology
- 出版年：2016
- 出版时间：March-May 2016
- 年：2016
- 卷：95
- 期：3-5
- 页码：136-152
- 全文大小：4851 K
文摘
- •
Cephalic NCCs migrate chemotactically to a concentration gradient of Shh morphogen.
- •
Expression of Shh at optic vesicle and Ptch–Smo on NCCs integrate the guide system.
- •
Molecular and pharmacological blocking inhibits oriented migration of cephalic NCC.
- •
Shh-dependent chemotaxis of NCCs was altered by in vitro-in vivo ethanol exposure.
- •
Results support a guiding activity for Shh in addition to its other canonic functions.