The KYxxL motif in Rad17 protein is essential for the interaction with the 9-1-1 complex
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- 作者：Yasunori Fukumotoa ; fukumoto@faculty.chiba-u.jp" class="auth_mail" title="E-mail the corresponding author ; Masayoshi Ikeuchib ; Yuji Nakayamab ; Naoto Yamaguchia ; nyama@faculty.chiba-u.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：DNA damage response ; Cell cycle checkpoint ; ATR ; Rad9 ; Rad17 ; The 9&ndash ; 1&ndash ; 1 complex
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：2 September 2016
- 年：2016
- 卷：477
- 期：4
- 页码：982-987
- 全文大小：1589 K
文摘
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We have identified a conserved KYxxL motif in Rad17 protein.
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The KYxxL motif is crucial for the interaction with the 9–1–1 complex.
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The KYxxL motif is dispensable or inhibitory for UV-induced Rad17 phosphorylation.
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Nucleotide binding of Rad17 is required for its nuclear localization.