Production optimization of ⁹⁹Mo/^99mTc zirconium molybate gel generators at semi-automatic device: DISIGEG

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• 作者：F. Monroy-Guzman^a ;   ; ^{fabiola.monroy@inin.gob.mx} ; T. Rivero Gutié ; rrez^a ;   ; ^{tonatiuh.rivero@inin.gob.mx} ; I.Z. Ló ; pez Malpica^a ; S. Hern&#225 ; ndez Cortes^a ; P. Rojas Nava^a ; J.C. Vazquez Maldonado^a ; A. Vazquez^b
• 关键词：Generator ; Mo-99 ; Tc-99m ; Molybdates ; Zirconium
• 刊名：Applied Radiation and Isotopes
• 出版年：2012
• 出版时间：January 2012
• 年：2012
• 卷：70
• 期：1
• 页码：103-111
• 全文大小：576 K

文摘

DISIGEG is a synthesis installation of zirconium ⁹⁹Mo-molybdate gels for ⁹⁹Mo/^99mTc generator production, which has been designed, built and installed at the ININ. The device consists of a synthesis reactor and five systems controlled via keyboard: (1) raw material access, (2) chemical air stirring, (3) gel dried by air and infrared heating, (4) moisture removal and (5) gel extraction. DISIGEG operation is described and dried condition effects of zirconium ⁹⁹Mo- molybdate gels on ⁹⁹Mo/^99mTc generator performance were evaluated as well as some physical¨Cchemical properties of these gels. The results reveal that temperature, time and air flow applied during the drying process directly affects zirconium ⁹⁹Mo-molybdate gel generator performance. All gels prepared have a similar chemical structure probably constituted by three-dimensional network, based on zirconium pentagonal bipyramids and molybdenum octahedral. Basic structural variations cause a change in gel porosity and permeability, favouring or inhibiting ^99mTcO₄^{?/sup> diffusion into the matrix. The 99mTcO₄?/sup> eluates produced by 99Mo/99mTc zirconium 99Mo-molybdate gel generators prepared in DISIGEG, air dried at 80 ¡ãC for 5 h and using an air flow of 90 mm, satisfied all the Pharmacopoeias regulations: 99mTc yield between 70?5 % , 99Mo breakthrough less than 3¡Á10? % , radiochemical purities about 97 % sterile and pyrogen-free eluates with a pH of 6.}