The role of ¡®eat-me¡¯ signals and autophagy cargo receptors in innate immunity

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• 作者：Keith B. Boyle ; Felix R ; ow
• 刊名：Current Opinion in Microbiology
• 出版年：2013
• 出版时间：June, 2013
• 年：2013
• 卷：16
• 期：3
• 页码：339-348
• 全文大小：1298 K

文摘

Selective autophagy is an important effector mechanism of cell autonomous immunity, in particular against invasive bacterial species. Anti-bacterial autophagy is activated by rupture of bacteria-containing vacuoles and exposure of bacteria to the cytosol. The autophagy cargo receptors p62, NDP52 and Optineurin detect incoming bacteria that have become associated with specific ¡®eat-me¡¯ signals such as Galectin-8 and poly-ubiquitin and feed them into the autophagy pathway via interactions with phagophore-associated ATG8-like proteins. Here we review recent progress in the field regarding the origin of bacteria-associated ¡®eat-me¡¯ signals, the specific roles of individual cargo receptors and how disrupting cargo receptor function may be important for bacterial evasion of autophagy.