Long noncoding RNAs: Re-writing dogmas of RNA processing and stability
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- 作者：Jeremy E. Wilusz wilusz@mail.med.upenn.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：MALAT1 ; MEN β ; NEAT1 ; Triple helix ; tRNA-like ; Sno-lncRNA ; Circular RNA ; CircRNA ; Pre-mRNA splicing ; RNA stability ; Polyadenylation
- 刊名：Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：1859
- 期：1
- 页码：128-138
- 全文大小：909 K
文摘
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Many abundant long noncoding RNAs lack a canonical 5′ cap and/or a poly(A) tail.
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MALAT1 is mis-regulated in many cancers and is processed by tRNA biogenesis factors.
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The 3′ ends of the long MALAT1 and MEN β transcripts are protected by triple helices.
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Sno-lncRNAs accumulate in the nucleus and have snoRNA structures at their ends.
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Pre-mRNA splicing generates many circular noncoding RNAs from protein-coding genes.