Markers of sympathetic nervous system activity associate with complex plasma lipids in metabolic syndrome subjects

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• 作者：Paul J. Nestel^a ; ^{paul.nestel@bakeridi.edu.au} ; Anmar A. Khan^a ; ^b ; ^c ; Nora E. Straznicky^a ; Natalie A. Mellett^a ; Kaushala Jayawardana^a ; Piyushkumar A. Mundra^a ; Gavin W. Lambert^a ; Peter J. Meikle^a ; ^b
• 关键词：Sympathetic nervous system activity ; Metabolic syndrome ; Lipidomics ; Norepinephrine ; NEFA ; Insulin resistance
• 刊名：Atherosclerosis
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：256
• 期：Complete
• 页码：21-28
• 全文大小：273 K
• 卷排序：256

文摘

Sympathetic nervous system activity (SNS) and insulin resistance (IR) are related in obesity. Complex lipid classes were found to be associated with SNS independently of IR. Plasma levels of these lipids differed between MetS and healthy subjects. These sphingolipids, ceramides and phospholipids are involved in neurotransmission. Complex lipids may partly explain SNS overactivity in obesity via neurotransmission.