Subfoveal Choroidal Thickness during Aflibercept Therapy for Neovascular Age-Related Macular Degeneration: Twelve-Month Results

详细信息    查看全文

• 作者：Hideki Koizumi ; MD ; PhD¹ ; ^{koizumi.hideki@twmu.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Mariko Kano ; MD² ; Akiko Yamamoto ; MD³ ; Masaaki Saito ; MD ; PhD² ; Ichiro Maruko ; MD ; PhD¹ ; Tetsuju Sekiryu ; MD ; PhD² ; Annabelle A. Okada ; MD ; PhD³ ; Tomohiro Iida ; MD ; PhD¹
• 关键词：AMD ; age-related macular degeneration ; CNV ; choroidal neovascularization ; IAI ; intravitreal aflibercept injection ; ICGA ; indocyanine green angiography ; OCT ; optical coherence tomography ; PCV ; polypoidal choroidal vasculopathy ; PDT ; photodynamic therapy ; RPE ; retinal pigment epithelium ; VEGF ; vascular endothelial growth factor
• 刊名：Ophthalmology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：123
• 期：3
• 页码：617-624
• 全文大小：826 K

文摘

To investigate changes in subfoveal choroidal thickness after intravitreal aflibercept injections (IAIs) for neovascular age-related macular degeneration (AMD) at 12 months.

Design

Retrospective, consecutive, interventional case series.

Participants

One hundred forty-four patients with treatment-naïve neovascular AMD examined at 3 university hospitals.

Methods

After a loading phase of 3 monthly 2.0-mg IAIs, the patients were injected bimonthly with additional rescue injections performed for worsening. Subfoveal choroidal thickness in IAI-treated eyes was evaluated using enhanced depth imaging optical coherence tomography (OCT) or swept-source OCT.

Main Outcome Measures

Changes in subfoveal choroidal thickness over a 12-month period.

Results

Of the 144 treated eyes, 58 (40.3%) had typical neovascular AMD and 86 (59.7%) had polypoidal choroidal vasculopathy (PCV). The mean subfoveal choroidal thickness of treated eyes decreased from 268.1±101.3 μm at baseline to 233.0±99.7 μm at 3 months and remained unchanged at 232.4±99.6 μm at 12 months (percentage decrease, 13.3% at 12 months compared with baseline; P < 0.0001), although there was some fluctuation in between treatments. This decrease in subfoveal choroidal thickness was associated significantly with gain in visual acuity for PCV eyes (P = 0.0087; R = 0.28), but not for eyes with typical neovascular AMD (P = 0.17; R = 0.18). Eyes without persistent or recurrent retinal fluid after the loading phase showed greater decrease in subfoveal choroidal thickness compared with those with persistent or recurrent retinal fluid, in both typical neovascular AMD (P = 0.042) and PCV (P = 0.038) eyes.

Conclusions

Subfoveal choroidal thickness decreased over 12 months with IAI therapy in eyes with neovascular AMD. Changes in subfoveal choroidal thickness after IAIs seem to be related to visual and anatomic outcomes.