The effect of the carotenoid bixin and annatto seeds on hematological markers and nephrotoxicity in rats subjected to chronic treatment with cisplatin

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• 作者：Lucé ; ia F. Souza^a ; ^{luceia.souza@ufrgs.br" class="auth_mail" title="E-mail the corresponding author} ; Carlos Henrique Pagno^a ; Niara da S. Medeiros^b ; Sí ; lvia Barbosa^c ; Paula C.P. dos Santos^b ; Alessandro Rios^a ; Matilde Achaval^c ; Erna V. de Jong^a
• 关键词：Cisplatin ; Bixin ; Annatto ; Cell differentiation ; Nephrotoxicity ; Antioxidant
• 刊名：Revista Brasileira de Farmacognosia
• 出版年：2016
• 出版时间：July-August 2016
• 年：2016
• 卷：26
• 期：4
• 页码：446-450
• 全文大小：836 K

文摘

This study assessed the protective effect of the carotenoid bixin and annatto seeds against possible nephrotoxicity induced with a single peritoneal administration of pharmacological cisplatin in male Wistar rats. After 48 h, the blood cell differential count showed a significant reduction in neutrophil counts in rats that received a diet rich in bixin when compared to the group that received only cisplatin. The use of cisplatin led to an increase in kidney weight. The carotenoid bixin attenuated renal injury, characterized by increased polymorphonuclear infiltration. No protective effect was observed with respect to Annatto. These results demonstrate the role of toxic cisplatin and suggest that bixin affords a protective effect against cisplatin-induced nephrotoxicity in adult Wistar rats.