Update of neurotrophic factors in neurobiology of addiction and future directions

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• 作者：Maryna Koskela^a ; Susanne Bä ; ck^c ; Vootele Võ ; ikar^b ; Christopher T. Richie^c ; Andrii Domanskyi^a ; Brandon K. Harvey^c ; Mikko Airavaara^a ; ^{mikko.airavaara@helsinki.fi}
• 刊名：Neurobiology of Disease
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：97
• 期：part_PB
• 页码：189-200
• 全文大小：1020 K
• 卷排序：97

文摘

Drug addiction is a chronic brain disease and drugs of abuse cause long lasting neuroadaptations. Addiction is characterized by the loss of control over drug use despite harmful consequences, and high rates of relapse even after long periods of abstinence. Neurotrophic factors (NTFs) are well known for their actions on neuronal survival in the peripheral nervous system. Moreover, NTFs have been shown to be involved in synaptic plasticity in the brain. Brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) are two of the most studied NTFs and both of them have been reported to increase craving when administered into the mesocorticolimbic dopaminergic system after drug self-administration. Here we review recent data on BDNF and GDNF functions in addiction-related behavior and discuss them in relation to previous findings. Finally, we give an insight into how new technologies could aid in further elucidating the role of these factors in drug addiction.