Lymphocyte subsets as biomarkers of therapeutic response in Fingolimod treated Relapsing Multiple Sclerosis patients

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• 作者：D Paolicelli^a ; ^{damiano.paolicelli@uniba.it} ; A Manni^a ; M D'Onghia^a ; V Direnzo^a ; P Iaffaldano^a ; S Zoccolella^a ; V Di Lecce^a ; C Tortorella^a ; G Specchia^b ; M Trojano^a
• 关键词：Multiple Sclerosis biomarkers ; Immune system re-modulation ; Fingolimod ; Lymphocytes ; Lymphocyte subsets
• 刊名：Journal of Neuroimmunology
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：303
• 期：Complete
• 页码：75-80
• 全文大小：565 K
• 卷排序：303

文摘

Fingolimod (FTY) induces a re-modulation of the immune system. Lymphocytes subsets may predict Multiple Sclerosis disease activity in FTY patients. Immune system re-modulation can be a biomarker of FTY therapeutic response. ROC curves stratified patients for the risk of relapse at T6 and Gd + lesions at T12.