Abnormal response of distal Schwann cells to denervation in a mouse model of motor neuron disease
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- 作者：Dario I. Carrascoa ; Ben A. Bahrc ; Kevin L. Seburnb ; Martin J. Pintera ; mpinter@emory.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Motor neuron disease ; Schwann cell ; Neurodegeneration ; Motor terminal ; Denervation cell death
- 刊名：Experimental Neurology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：278
- 期：Complete
- 页码：116-126
- 全文大小：1887 K
文摘
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The response of Schwann cells (SCs) to denervation was studied in muscles of SOD1G93A mice
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At P30 or P60, S100 labeling quickly disappeared from SOD1G93A neuromuscular junctions (NMJs) and from preterminal regions of endplate bands
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These effects did not depend on loss of activity and were not specific for S100 labeling
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Other evidence suggests that distal SCs may be lost after denervation of SOD1G93A muscles
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The response of SOD1G93A distal SCs to denervation will slow or inhibit reinnervation following disease-related denervation