Neuronal low-density lipoprotein receptor-related protein 1 (LRP1) enhances the anti-apoptotic effect of intravenous immunoglobulin (IVIg) in ischemic stroke
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- 作者：Ker Zhing Loka ; b ; Silvia Manzaneroc ; s.manzanero@uq.edu.au" class="auth_mail" title="E-mail the corresponding author ; Thiruma V. Arumugama ; b ; d ; phstva@nus.edu.sg" class="auth_mail" title="E-mail the corresponding author
- 关键词：APP ; amyloid precursor protein ; BBB ; blood brain barrier ; IFN-γ ; interferon-gamma ; IVIg ; Intravenous immunoglobulin ; I/R ; ischemia and reperfusion ; LDL ; low-density lipoprotein ; LRP1 ; low-density lipoprotein receptor-related protein 1 ; LPS ; lipopolysaccharide ; MAPKs ; mitogen-activated protein kinases ; NF-κB ; Nuclear factor-κB ; OGD ; oxygen and glucose deprivation ; RAP ; receptor associated protein ; TLR ; toll like receptor
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 August 2016
- 年：2016
- 卷：1644
- 期：Complete
- 页码：192-202
- 全文大小：3188 K
文摘
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The low-density lipoprotein receptor-related protein-1 is a multifunctional receptor.
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The capacity of IVIg to modulate LRP1 in neurons are thus far unknown.
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IVIg protects ischemic neurons by preventing the dephosphorylation of LRP1.
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Ischemia decreases LRP1 levels and phosphorylation, and IVIg blocks these effects.
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LRP1 supports IVIg in its ability to suppress multiple pro-death signaling pathways.